The Israeli government urged residents in the occupied Golan Heights to stay close to shelters amid a large-scale Iranian retaliatory attack on Israel.
Israeli television reported that residents of Eilat, Dimona and Nevatim in the Negev Desert received similar instructions.
The Golan Heights and an Israeli airbase in the Negev Desert were expected to be targets of Iranian attacks, US media reports citing Israeli representatives said.
Dozens of Israeli fighter jets were sent out to intercept missiles from Iran.